描述：2'- Fluoro-NTP在新藥開(kāi)發(fā)和研究中的利用數(shù)量逐漸增加。同時(shí)也用于寡核苷酸適配子和siRNA的設(shè)計(jì)和合成，增強(qiáng)外源DNA在生物體內(nèi)的穩(wěn)定性。
2'- Fluoro-NTP
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2'- Fluoro-NTP在新藥開(kāi)發(fā)和研究中的利用數(shù)量逐漸增加。zui近，2' Fluoro ATP被證實(shí)是研究制藥適用激酶時(shí)篩選ATP需求酶的通用工具。2' Fluoro NTPs能與酶兼容提高DNA和RNA在體內(nèi)的穩(wěn)定性。2' Fluoro NTPs常用于寡核苷酸適配子和siRNA的設(shè)計(jì)和合成，因?yàn)樗隗w內(nèi)的傳送增加了靶分子的親和力，阻礙核酸酶的作用，同時(shí)降低免疫反應(yīng)。2' Fluoro NTP是非常不錯(cuò)的DNA和RNA聚合酶，包括廣泛使用的T7 RNA聚合酶的底物。
| 2' Fluoro Nucleoside Triphosphates | |||
| N-1007-1 | 2'-Fluoro-2'-deoxyadenosine-5'-TP | 1umole | 1317.5 |
| N-1007-5 | 2'-Fluoro-2'-deoxyadenosine-5'-TP | 5umoles | 6205 |
| N-1007-10 | 2'-Fluoro-2'-deoxyadenosine-5'-TP | 10umoles | 10625 |
| N-1008-1 | 2'-Fluoro-2'-deoxycytidine-5'-TP | 1umole | 892.5 |
| N-1008-5 | 2'-Fluoro-2'-deoxycytidine-5'-TP | 5umoles | 4335 |
| N-1008-10 | 2'-Fluoro-2'-deoxycytidine-5'-TP | 10umoles | 7055 |
| N-1009-1 | 2'-Fluoro-2'-deoxyguanosine-5'-TP | 1umole | 1657.5 |
| N-1009-5 | 2'-Fluoro-2'-deoxyguanosine-5'-TP | 5umoles | 7905 |
| N-1009-10 | 2'-Fluoro-2'-deoxyguanosine-5'-TP | 10umoles | 14450 |
| N-1010-1 | 2'-Fluoro-2'-deoxyuridine-5'-TP | 1umole | 892.5 |
| N-1010-5 | 2'-Fluoro-2'-deoxyuridine-5'-TP | 5umoles | 4335 |
| N-1010-10 | 2'-Fluoro-2'-deoxyuridine-5'-TP | 10umoles | 7055 |
| N-1055-1 | 2'-Fluoro-thymidine-5'-TP | 1umole | 1317.5 |
| N-1055-5 | 2'-Fluoro-thymidine-5'-TP | 5umoles | 6205 |
| N-1055-10 | 2'-Fluoro-thymidine-5'-TP | 10umoles | 10625 |
